Neurobiology of Disease BDNF Signaling in the VTA Links the Drug-Dependent State to Drug Withdrawal Aversions
نویسندگان
چکیده
Hector Vargas-Perez,1 Amine Bahi,2 Mary Rose Bufalino,3 Ryan Ting-A-Kee,1 Geith Maal-Bared,1 Jenny Lam,1 Ahmed Fahmy,1 Laura Clarke,1 Jennifer K. Blanchard,4 Brett R. Larsen,4 Scott Steffensen,4 Jean-Luc Dreyer,5 and Derek van der Kooy1,3 1Department of Molecular Genetics, Neurobiology Research Group, University of Toronto, Toronto, Ontario, M5S3E1 Canada, 2Department of Anatomy, Faculty of Medicine and Health Sciences, United Arab Emirates University, Alabama Ain, 17666 United Arab Emirates, 3Department of Medical Biophysics, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, M5S3E1 Canada, 4Department of Psychology and Center for Neuroscience, Brigham Young University, Provo, UT 84602, and 5Department of Medicine, Division of Biochemistry, University of Fribourg, Fribourg 1700, Switzerland
منابع مشابه
BDNF signaling in the VTA links the drug-dependent state to drug withdrawal aversions.
Drug administration to avoid unpleasant drug withdrawal symptoms has been hypothesized to be a crucial factor that leads to compulsive drug-taking behavior. However, the neural relationship between the aversive motivational state produced by drug withdrawal and the development of the drug-dependent state still remains elusive. It has been observed that chronic exposure to drugs of abuse increas...
متن کاملA single administration of the hallucinogen, 4-acetoxy-dimethyltryptamine, prevents the shift to a drug-dependent state and the expression of withdrawal aversions in rodents.
Despite several studies suggesting the therapeutic use of 5-hydroxytryptamine receptors type 2A (5-HT2A ) agonists in the treatment of substance use disorders, the neurobiological basis accounting for such effects are still unknown. It has been observed that chronic exposure to drugs of abuse produces molecular and cellular adaptations in ventral tegmental area (VTA) neurons, mediated by brain-...
متن کاملاثر مخالف بوپروپیون در هسته VTA روی رفتارهای جویدن و فرار از قفس در موش های وابسته به مرفین پس از القاء محرومیت بوسیله نالوکسان
Received: 5 Sep, 2010 Accepted: 26 Oct, 2010 Abstract: Background &Aims : Bupropion is a unique, non-nicotinic smoking cessation agent despite its effective antidepression effect. It is a NE and DA reuptake inhibitor and as well as a nicotinic acetylcholine receptor antagonist. Beside its smoking cessation effects it can reduces some symptoms of nicotinic withdrawal signs. DA neurons ...
متن کاملImprovement of Learning and Memory Deficits With Aerobic Training and Donepezil Co-therapy in Amyloid-β Injected Male Rats Through the CREB And BDNF Signaling Pathway
Background: Accumulation of amyloid-β (Aß) plaques, primarily in the hippocampus, leads to neuronal death and Alzheimer disease. Exercise and medications can prevent and treat neuronal diseases. This study aimed to determine the effects of aerobic training and donepezil, a medication used in Alzheimer disease, on the improvement of learning and memory deficits in Aß-injected male rats. Methods...
متن کاملA comparative study on the effect of L-arginine and morphine in induction of conditioned place preference in rat
It has been shown that L-arginine like the abused drugs could release dopamine from meso-cortico-limbic system. The purpose of the present study was to compare the effect of L-arginine with morphine as a standard abuse drug in the induction of conditioned place preference (CPP) in rat. For this purpose, male Wistar rats (250-300 g) were used in the experiments. Five days after surgical cannulat...
متن کامل